Decades since their successful television series was canceled, Chip has succumbed to a life of suburban domesticity as an insurance salesman. Dale, meanwhile, has had CGI surgery and works the nostalgia convention circuit, desperate to relive his glory days. When a former cast mate mysteriously disappears, Chip and Dale must repair their broken friendship and take on their Rescue Rangers detective personas once again to save their friend’s life.

Lorsqu'une fusillade entre cartels fait plusieurs morts parmi les agents de la DEA, un policier vieillissant doit retrouver un témoin oculaire et l'escorter de l'autre côté de la frontière. Mais lorsqu'il apprend que l'attaque a été exécutée par les forces américaines, il ne sait plus à quel camp se fier...